Sunday, December 11

Doxycycline Hyclate 100mg Is The Ideal Antidote For Bacterial Infection

A member of the family of tetracycline antibiotics. Doxycycline is a drug molecule that is commonly administered upon patients suffering from bacterial infections. The molecule is now marketed under the brand name of Doxycycline Hyclate by which is it globally known. It is a prescription antibiotic drug that is FDA approved to treat a number of infections. Some primary ones being acne condition, gum disorders, bacterial infections, rosacea, etc. So, if you are suffering from a contagion that is diagnosed or strongly suspected to be the result of bacterial attack. Then a dosage of Doxycycline Hyclate 100mg is a generous one to treat the condition.

is 50 mg that is succeeded by the 100 mg strength. The medicine contains inactive components like croscarmellose sodium, anhydrous lactose, gelatin, FD&C Blue 1, D&C Red 28, magnesium stearate, titanium dioxide and microcrystalline cellulose. Each 100gm of the molecule contains Doxycycline Hyclate 100mg. Which is similar to the same quantity of Doxycycline alone. The strength of the dose varies depending upon the severity of the condition of the patient. Plenty of fluid (preferably water) should be consumed with the tablet while seated in an upright position. This is necessitated as the medication is likely to cause throat irritation due to its inactive ingredients.

. The molecule was known to make hormonal contraception ineffective. However, recent studies have nullified this finding and have added that no signs of significant loss in the efficacy of oral contraceptives have been seen. The medicine can be had regardless of dietary habits. It has been found out that even dairy products do not pose any hindrance to Doxycycline absorption in the blood. However, the drug is not approved to be used upon children.

Doxycycline Hyclate 100mg is applicable on kids only in specific exceptions when fatal infections can be cured with no other alternative.

Pharmacological action Doxycycline Hyclate 100 mg

Semisynthetic tetracycline, a bacteriostatic broad-spectrum antibiotic. Penetrating inside the cell, acts on intracellular pathogens are located. Inhibits protein synthesis in the microbial cell. Breaks communication transport of aminoacyl-RNA 30S subunit ribosomal with the membrane. To it are highly sensitive. Gram-positive microorganisms Staphylococcus spp. (Including Staphylococcus aureus, Staphylococcus epidermidis), Streptococcus spp. (Including Streptococcus pneumoniae), Clostridium spp, Listeria spp, And gram-negative bacteria.

Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilusinfluenzae, Klebsiella spp. Entamoeba histolytica, Escherichia coli, Shigella spp, Enterobacter, Salmonella spp. Yersinia spp, Formerly Pasteurella spp, Bacteroides spp, Treponema spp. Including strains resistant to other antibiotics such as penicillins and cephalosporins date.

The most susceptible Haemophilusinfluenzae 91-96% and intracellular pathogens. Doxycycline is active against most pathogens of dangerous infectious diseases: plague, tularemia, anthrax bacteria, Legionella, Brucella, Vibrio cholerae, rickettsia, agents of glanders, Chlamydia ornithosis agents, psittacosis, trachoma, venereal granuloma. It operates on most strains of Proteus, Pseudomonas aeruginosa, and fungi. To a lesser extent than other tetracycline antibiotics.

Inhibits the intestinal flora, which is different from the more complete absorption and longer duration of action. According to the degree of antibacterial activity of doxycycline superior natural tetracycline. In contrast to tetracycline and oxytetracycline has a higher therapeutic efficacy. Which is manifested in the treatment of 10-fold lower doses and longer duration of action. There is cross-resistance to other tetracyclines, as well as to penicillins.

doxycycline hyclate 100mg

Indications Doxycycline Hyclate 100 mg

Infectious and inflammatory diseases caused by susceptible organisms: respiratory tract infections (pharyngitis, acute and chronic bronchitis, tracheitis, bronchopneumonia, lobar pneumonia, lung abscess, empyema), upper respiratory tract infection (otitis media, tonsillitis, sinusitis, etc.), infections urogenital system (cystitis, pyelonephritis, prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, endometritis, endocervicitis, acute orhiepididimit, gonorrhea) infection and biliary tract (cholecystitis, cholangitis, gastroenterocolitis, bacillary dysentery, diarrhea, traveler) skin infections and soft tissue (cellulitis, abscesses, furunculosis, panaritiums, infected burns, wounds, etc).

Eye infections, syphilis, yaws, yersiniosis, legionellosis, rickettsial disease, chlamydia, various locations (including prostatitis and proctitis), Q fever , Rocky Mountain spotted fever, typhus (including typhus, tick-borne relapsing). Lyme disease (Lyme disease) 1st.Bbacillary and amoebic dysentery, tularemia, cholera, actinomycosis, malaria, and in combination therapy leptospirosis, trachoma, psittacosis, ornithosis, granulocytic ehrlichiosis, whooping cough, brucellosis, osteomyelitis, septicemia, subacute bacterial endocarditis, peritonitis. Prevention of postoperative septic complications of malaria caused by Plasmodium falciparum, during short trips (less than 4 months) in an area where common strains resistant to chloroquine and or pyrimethamine-sulfadoxine.

Contraindications Doxycycline Hyclate 100 mg

Hypersensitivity, porphyria, severe liver failure, leukopenia, pregnancy II-III trimester, lactation, infancy up to 8 years the possibility of the formation of insoluble complexes of Ca2 + from the deposition in the skeleton, enamel and dentin of the teeth. For in the introduction myasthenia gravis.

Side effects Doxycycline Hyclate 100 mg

The nervous system benign intracranial hypertension anorexia, vomiting, headache, papilledema, toxic effects on the central nervous system dizziness or instability. Part of the digestive system: nausea, constipation or diarrhea, glossitis, dysphagia, esophagitis including erosive gastritis, gastric ulcers and 12 duodenal ulcer, enterocolitis due to the proliferation of resistant strains of staphylococci.

Allergic reactions: maculopapular rash, pruritus, skin flushing, angioedema, anaphylactoid reactions, drug lupus erythematosus. On the part of hematopoiesis: hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia. Other: photosensitivity, superinfection, sustainable change in color of tooth enamel, inflammation of the anogenital area of the perineum. Candidiasis vaginitis, glossitis, stomatitis, proctitis, goiter.

g teeth yellow-gray-brown color, as well as enamel hypoplasia. During the infusion solution should be protected from light sunlight and artificial.

It can not be administered simultaneously with other drugs. Perhaps a false increase in catecholamines in the urine when determining the fluorescence method. In the study of the thyroid gland biopsy in patients receiving long-term doxycycline. Possibly a dark brown staining in tissue micropreparations without compromising its function.

The experiment found that doxycycline may have a toxic effect on fetal development delayed skeletal development. Blocks metalloproteinases enzymes that catalyze the degradation of collagen and proteoglycans. In the cartilage, leads to a reduction of lesions in deforming osteoarthrosis. With increasing doses above 4 g pharmacokinetics of doxycycline does not depend on the dose and blood concentration does not increase. As a preparation of “first” number of patients assigned to 65 at exacerbation of chronic bronchitis including on the background of asthma. Without concomitant diseases such deterioration is often caused by Haemophilusinfluenzae.

Effective with acute bronchopulmonary infection usually staphylococcal etiology in patients with cystic fibrosis, chlamydial arthritis, granulocytic ehrlichiosis. Elderly patients used to treat acute prostatitis and urinary infections caused by Escherichia coli. In combination with quinine is highly effective in treating malaria.

Interaction Doxycycline Hyclate 100 mg

Absorbance decrease antacids containing Al3 +, Mg2 +, Ca2 +, drugs Fe, sodium bicarbonate, Mg2 +-containing laxatives, kolestiramin and colestipol, so their use should be divided every 3 h. Due to the suppression of intestinal microflora reduces the prothrombin index, which requires correction dose proximity anticoagulants. In combination with bactericidal antibiotics disturb the synthesis of cell wall penicillins, cephalosporins, the effectiveness of recent declines.

Reduces the reliability of contraception and increases the frequency of bleeding “breakthrough” in patients receiving estrogen oral contraceptives. Ethanol, barbiturates, rifampin, carbamazepine, phenytoin and other stimulants of microsomal oxidation, accelerating the metabolism of doxycycline, reducing its concentration in plasma. Simultaneous application of retinol improves intracranial pressure.

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